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欧洲幽门螺杆菌治疗共识 5

False Negative on a biopsy? Really need some help...

There are several types of tests for H.pylori. The major ones have a their own forum.

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False Negative on a biopsy? Really need some help...

Post by bobby_jo » Tue Jul 17, 2018 2:28 am

Like many of you, I have been dealing with hell for a while now - I'm female, and in my early 40s. This all started for me a little over two years ago, and my symptoms have gotten increasingly worse:

* constant nausea
* ridiculously bloated
* acid reflux that has zero help from PPIs, Tums, etc.
* constant belching
* weird bowel movements - I haven't had a solid BM in months. Usually it comes out pencil thin, flaky, or just disintegrates in the bowl.
* occasional vomiting
* constant burning pain in abdomen. It hurts if I don't eat. It hurts if I eat.
* really bad burning pain under right rib (much better after gallbladder removed, but not wholly gone)
* "scraped" feeling inside my intestines. I tell my husband it feels like I swallowed a pine cone that is moving through my insides.
* constant fatigue and tired feeling (may be due to me not eating much)
* weight loss; have lost 30 pounds and am now reaching the point where I can't afford to lose much more

My doctors have done all kinds of colonoscopies, endoscopies, and other fun stuff. I've been given PPIs, which did nothing. Finally, as a "Well, we dont' know what's wrong with you, but your gallbladder seems to be in bad shape" response, I had it removed a couple of months ago. I felt a lot better the first few weeks, and then it all went to hell again (my personal suspicion: the antibiotics they gave me during the surgery knocked whatever the heck I have down a few notches before it started growing again).

During one of the endoscopies about 4 months ago, they finally did a biopsy to check for H. pylori. Note: during that time, I had been on PPIs as well as a minor antiobiotic (Macrodantin) for something else. The test result was negative.

My questions:

1. Does this sound like H. pylori, based on the symptoms above?
2. I did some poking online, and it sounds like if you're on PPIs, it can give you a false negative. True?

Any help is greatly appreciated...

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Re: False Negative on a biopsy? Really need some help...

Post by Helico_expert » Tue Jul 17, 2018 9:21 am

H. pylori causes all sort of gastric problem. So some of your symptoms do look like H. pylori. But you cannot tell for sure until you do a breath test.

it is true that PPI can lead to false negative breath test. It is best you switch to H2 blocker for at least 2 weeks. Then you can continue H2 blocker until the night before breath test. H2 blocker is fast acting, but stay in your body only for a short time. PPI on the other hand is slow acting, but stay in your body for longer time.

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Re: False Negative on a biopsy? Really need some help...

Post by LeslieAJ » Tue Jul 17, 2018 11:01 am

A lot of your symptoms sound like Candida. I was diagnosed with Candida and I’ve been dealing with it for a couple years, but the underlying problem is Hpylori. All the inflammation and leaky gut causes your gut to be open to a bunch of other issues. I’ve been dealing with it all naturally, and works pretty well for me, especially the Candida. But have to get rid of the H pylori or the Candida keeps coming back.

Bloating sounds like Sibo. I have found functional doctor is a lot more helpful.

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