Helico_expert wrote: ↑Mon Nov 25, 2019 11:38 am
the only one you have not tried is furazolidone.
Unfortunately furazolidone is not available in USA. It is no longer FDA-approved due to cancer concerns so not available to prescription here:
https://en.wikipedia.org/wiki/Furazolidone
"Since furazolidone is a nitrofuran antibiotic, its use in food animals is currently prohibited by the FDA under the Animal Medicinal Drug Use Clarification Act, 1994.[5]
Furazolidone is no longer available in the US."
Talicia is not available yet in the US but should be in the first quarter of 2020. But I already did 14-day rifabutin/amoxicillin/omeprazole combination (actually switched mid-treatment to pantaprazole) back in March and it failed so I'm not sure how it would work better next time. Plus each time I go on amoxicillin I have to go through desensitization procedure and my allergist is adamant I shouldn't go through that again, or at least not for a while. I have been through the procedure 3x in the past year for 3 different H. Pylori treatments to include amoxicillin and it is very hard on my system.
Helico_expert wrote: ↑Mon Nov 25, 2019 11:38 am
it might work for you because it has large dose of PPI. you can probably boost this treatment with bismuth 220mg QID too.
Every treatment over the past year has had PPI 20mg/3x day except for last treatment which was 40mg/3x day PPI with high dose amoxicillin 3000mg/day, still didn't work
Helico_expert wrote: ↑Mon Nov 25, 2019 11:38 am
blood test is not useful
cagA and vacA testing are also not useful
histology is good.
if the laboratory can do bacterial culture, that would be ideal.
Yes, we are going to do susceptibility testing again. The last sensitivity test showed most drugs were going to be ineffective except amoxicillin. After a few of those treatments I don't know if amoxicillin will even be as effective now.
Previously:
Amoxicillin: <=0.008
Ciprofloxacin: >2
Clarithroymycin: >0.5 Resistant
Metronidazole: 32
Tetracycline: 1
For past year over 4 separate blood tests, my ferritin has gone down and is now low at 10. My iron saturation is borderline low at 15. Strangely enough, my serum iron level is within normal range. I am constantly fatigued and things hurt all over my body.
My hemoglobin, hematrocrit, MCH levels have all been steadily decreasing, and my RDW level has been increasing and is now high at 16.1
I had read somewhere that high RDW with H. Pylori has some correlation to intestinal metaplasia. My last endoscopy only showed chronic gastritis due to H. Pylori. Do you have any information on that correlation? Is there any validity to it?
Last year I had numerous wacky blood test results: high gastrin, high Chronic Uriticaria index, very high CGA (without PPI use--leading my GP to think I had carcinoid which thankfully turned out not to be), very high N-methylhistamine levels. Not sure if these are related to H. Pylori infection.
I suppose the endoscopy result will answer my question, but the waiting on the results is going to be torture!
Please let me know if there is anything that stands out to you that might be related?
Thanks!