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欧洲幽门螺杆菌治疗共识 5

Upcoming H.Pylori treatment #7 - question on serum ferritin and sensitivity testing

There are several types of tests for H.pylori. The major ones have a their own forum.

Moderators: Toni, barjammar

Posts: 27
Joined: Fri May 17, 2019 2:45 am

Re: Upcoming H.Pylori treatment #7 - question on serum ferritin and sensitivity testing

Post by ankiwo72 » Tue Sep 10, 2019 4:09 am

chetanvenki wrote:
Mon Sep 09, 2019 9:20 pm

What does this sensitivity numbers mean, please eloberate on how much dosage of antibiotics would be susceptible with these numbers. I am due to get my susceptibility test result this week.
My understanding is that those numbers are the minimum amount of each antibiotic in micrograms the bacteria was susceptible to. In some cases the amount was too high to be considered an effective treatment option. Maybe the moderators can explain better?

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Re: Upcoming H.Pylori treatment #7 - question on serum ferritin and sensitivity testing

Post by Helico_expert » Tue Sep 10, 2019 8:54 am

Minimum Inhibition Concentration (or MIC) is the right term for antibiotic resistance determination.

according to the EUCAST guideline.
Quinolones MIC is 1 mg/L <- eg. ciprofloxacin
Tetracyclines MIC is 1 mg/L
Metronidazole MIC is 8 mg/L
Rifampicin MIC is 1 mg/L

according to the CLSI guideline.
Macrolides MIC is 1 mg/L <- eg. Clarithromycin

Although Amoxicillin MIC is set to be 0.125 mg/L, we think it should be 1 mg/L

If your H. pylori strain has a tolerance of these antibiotics greater than the listed MIC, then it is considered as resistant strain.
However, factors that may affect the MIC include
1. the methods of exposure of the antibiotics to the microorganism;
2. the brand (or purity) of the antibiotics; and
3. the technician handling the results.

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