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Does this therapy work??

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cyprian zimunya
Posts: 24
Joined: Mon Mar 11, 2019 5:25 pm

Does this therapy work??

Post by cyprian zimunya » Sun May 12, 2019 4:52 pm

I want to ask that does this therapy more effective to eradicate h pylori.. amox ig three times a day ,bismuth 120mg three times a day , metronidazole 200mg three times a day and esomeprazole 40mg 2 times a day... my main voncern is on metronidazole i have used it before so it might not work ..furazolidone is not widely spread in my country so i might not able to get it ..so is there other antibiotic that i can use instead of metronidazole or i can just use metronidazole since i heard you saying that metronidazole resistance can be overcomed when using another strong antibiotic

Helico_expert
Site Admin
Posts: 3124
Joined: Wed Mar 02, 2011 7:20 am

Re: Does this therapy work??

Post by Helico_expert » Sun May 12, 2019 9:56 pm

High dose PPI + High dose Amox + Bismuth may already give you a cure rate of 80%.

Metronidazole resistance has been shown to be able to be overcome when used with Tetracycline. Since The H. pylori will not become resistant to Amox and Bismuth, I think you can give this quadruple (PPI + Amox + Bismuth + Metro) a try.

If it failed, you can always repeat PPI + Amox + Bismuth + one other antibiotic.

cyprian zimunya
Posts: 24
Joined: Mon Mar 11, 2019 5:25 pm

Re: Does this therapy work??

Post by cyprian zimunya » Mon May 13, 2019 1:58 am

Ok i will take your recommendation thanks. What about if it failed what other antibiotic should i add there?...is tetracycline and amox the same or is it possible to add tetracycline there or i should not add it ,it will reduce the effectiveness of amox

Helico_expert
Site Admin
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Joined: Wed Mar 02, 2011 7:20 am

Re: Does this therapy work??

Post by Helico_expert » Mon May 13, 2019 8:40 am

very good question. In theory, Amox and Tetracycline should counter each other. But in practical they dont. I am not sure why.

So, Yes, tetracycline can be your next choice if your current therapy failed.

cyprian zimunya
Posts: 24
Joined: Mon Mar 11, 2019 5:25 pm

Re: Does this therapy work??

Post by cyprian zimunya » Mon May 13, 2019 10:05 am

Ok thanks so i can include tetracycline in my therapy if it failed ..so it will be amox,bismuth, tetracycline and ppi

Helico_expert
Site Admin
Posts: 3124
Joined: Wed Mar 02, 2011 7:20 am

Re: Does this therapy work??

Post by Helico_expert » Mon May 13, 2019 10:40 am

Yes. But hopefully your PBAM will work and you dont have to try PBAT.

cyprian zimunya
Posts: 24
Joined: Mon Mar 11, 2019 5:25 pm

Re: Does this therapy work??

Post by cyprian zimunya » Mon May 13, 2019 11:16 pm

Lets hope it will work i will talk to my doctor about. Is it possible to increase omeprazole dosage to 40mg twice a day

Helico_expert
Site Admin
Posts: 3124
Joined: Wed Mar 02, 2011 7:20 am

Re: Does this therapy work??

Post by Helico_expert » Tue May 14, 2019 9:17 am

yup. you can do 40mg twice a day.

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