The Helicobacter Foundation

Proven Therapies

Dual therapies

GENERIC NAME	DOSING	DURATION	CURE RATE (%)
omeprazole	20 mg BID	28 days	70-74
clarithromycin	500 mg TID	14 days

GENERIC NAME	DOSING	DURATION	CURE RATE (%)
ranitidine bismuth citrate	400 mg BID	28 days	73-84
clarithromycin	500 mg TID	14 days

GENERIC NAME	DOSING	DURATION	CURE RATE (%)
lansoprazole	30 mg TID	14 days	66-77
amoxycillin	1,000 mg TID	14 days

Triple Therapies

GENERIC NAME	DOSING	DURATION	CURE RATE (%)
bismuth subsalicylate	Two tablets (525 mg) QID	14 days	77-82
or			*( see note below)**
bismuth subcitrate	One tablet (120 mg) QID	14 days
metronidazole	250 mg QID	14 days
tetracycline	500 mg QID	14 days
H 2 antagonist	dose to heal ulcer	28 days

GENERIC NAME	DOSING	DURATION	CURE RATE (%)
lansoprazole	30 mg BID	14 days	86-92
amoxycillin	1,000 mg BID	14 days
clarithromycin	500 mg BID	14 days

Quadruple therapies

GENERIC NAME	DOSING	DURATION	CURE RATE (%)
bismuth subsalicylate	Two tablets (525 mg) QID	7 days	85-95
or			*( see note below)**
Colloidal bismuth subcitrate	One tablet (120 mg) QID	14 days
metronidazole	250 mg QID	7 days
tetracycline	500 mg QID	7 days
omeprazole	20 mg BID	7 days
or
lansoprazole	30 mg BID	7 days

=== =Generic name=====	====DOSING========	===DURATION====	====CURE RATE==
Colloidal bismuth subcitrate	120mg QID	14 days	72%
Furazolidone	100mg BID ***	14 days
Amoxycillin	1000mg BID	14 days
Omeprazole	20mg BID	14 days
	Double Furazolidone dose
Colloidal bismuth subcitrate	120mg QID	14 days	92%
Furazolidone	200mg BID***	14 days
Amoxycillin	1000mg BID	14 days
Omeprazole	20mg BID	14 days
	Marshall Therapy
=== =Generic name=====	====DOSING========	===DURATION====	====CURE RATE==
Amoxycillin	1000mg BID	14 days	90-92%
Omeprazole	40mg TDS (6 times normal dosage)	14 days
Ciprofloxacin	500mg BID	14 days
Rifabutin	150mg BID	14 days

	Cammarota et.al. (2000)
Rabeprazole (R)	20mg OD	7 days
Levofloxacin (L)	500mg OD	7 days	RLA Cure rate=92%
Amoxycillin (A)	1000mg BID)	7 days



Tinidazole (T)	500mg (BID)	7 days	RLT Cure rate =90%

	Nagahara et al. (2000)
Rabeprazole (R)	10mg BID	5 days
Amoxicillin (A)	750mg BID	5 days
Clarithromycin (C)	200mg BID	5 days	RAC Cure rate 86.7%(PP) 80% (ITT)
Metronidazole (M)	250mg BID	5 days	RACM Cure rate 98.1% (PP) 94.5% (ITT)

	Luth et al (2001)
Rabeprazole	20mg BID	4 days
Clarithromycin	500mg BID	4 days	Cure Rate =90%
Amoxycillin	1000mg BID	4 days

	Wong et al. 2003
Rabeprazole	20mg BID	7 days	Cure rate 91% (PP)
Rifabutin	300mg QID	7 days	Cure rate 91% (ITT)
Levofloxacin	500mg QID	7 days

	Wong et al (2003)
Rabeprazole	20mg BID	7 days
Colloidal Bismuth Subcitrate	120mg QID	7 days	Cure rate 92% (PP)
Metronidazole	400mg TID	7 days	Curea rate 91%(ITT)
Tetracycline	500mg QID	7 days

Therapies Under Evaluation

GENERIC NAME	DOSING	DURATION	CURE RATE (%)
omeprazole	20 mg BID	10-14 days	85-95
or			( * see note below)
lansoprazole	30 mg BID	10-14 days
clarithromycin	500 mg BID	10-14 days
metronidazole	500 mg BID	10-14 days

*Note: In some countries they have found that 7 days therapy with this regimen is equally effective.

GENERIC NAME	DOSING	DURATION	CURE RATE (%)
omeprazole	20 mg BID	10-14 days	85-95
or
lansoprazole	30 mg BID	10-14 days
clarithromycin	500 mg BID	10-14 days
amoxycillin	1,000 mg BID	10-14 days

GENERIC NAME	DOSING	DURATION	CURE RATE (%)
rantidine bismuth citrate	400 mg BID	10-14 days	80-95
clarithromycin	500 mg BID	10-14 days
amoxycillin	1,000 mg BID	10-14 days