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Question re: how to to take Quadruple therapy

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Helico_expert
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Re: Question re: how to to take Quadruple therapy

Post by Helico_expert » Thu Dec 08, 2016 1:54 am

Hi,

Bismuth is like a heavy metal. It cant be absorbed by the body. and it trick the bacteria that it is iron (which is required for its survival). So the bacteria die after taking up bismuth. Since it kills bacteria, it is seen as an antibiotic.

because H. pylori is so hard to spread, it is almost impossible to catch it from friends even if you share food or drinks. So, people under the same roof, because you expose to them daily, increase the risk slightly. Then again, the chance is very low especially when all of you is aware of personal hygiene. In modern society, H. pylori is becoming rare because of everyone's personal hygiene. So in modern society, even if we dont treat H. pylori infection, the prevalence will gradually go down after a few generations.

sparkling2006
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Re: Question re: how to to take Quadruple therapy

Post by sparkling2006 » Thu Dec 08, 2016 3:13 am

Thank you so much for the reply. Your team is really a blessing! This puts my mind at ease and fingers crossed this round can finally eradicate the bug.

Helico_expert
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Joined: Tue Mar 01, 2011 11:20 pm

Re: Question re: how to to take Quadruple therapy

Post by Helico_expert » Thu Dec 08, 2016 2:10 pm

You are welcome. Wish you all the best in your treatment.

sparkling2006
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Re: Question re: how to to take Quadruple therapy

Post by sparkling2006 » Mon Dec 12, 2016 10:56 am

Hi Helico Experts,

Got a few more questions which puzzles me now and then :

1. I am now on Day 13 of the 2-wk treatment (De-nol tab 4 times + Flagyl 4 times + Doxycycline 2 times +
Omeprazole 2 times). Does this therapy incur side effects incl. stomach fullness and farting/belching after eating ? I belched/farted sometimes before the therapy though and these seem to be there still. Would this mean the therapy did not work ?

2. My GI specialist just told me to stop all medications after this therapy and wait for 4 weeks to do another C13 UBT. My last upper endoscopy done in Oct shows mild gastritis and no other complications. Is it normal to just finish the eradication therapy without continuing the PPI to heal gastritis ? If it is needed to continue how long should the PPI be taken ?

3. Previously in Sep and Oct I had taken two triple therapies which failed to eradicate the bug. This is the 3rd round (Dec). Would these antibiotics aggravate my gastritis ?

4. Assuming this round also fails, can I wait for a few more months to start another therapy given that I am scared taking in too many antibiotics in last few months already ? Does antibiotic resistance stay on life term or will diminish after some time ?

BTW, My CEA index is very low and there is NO stomach cancer or generic cancerous patient in my family. I do not smoke/drink. My symptoms before the 1st therapy are mainly frequent burping/belching and chest tightness (but NO heartburn sensation), occasional breathing difficulty due to stomach gas, NO stomach pain. After the 2nd round therapy, symptoms were improved tremendously but still have occasional belching as mentioned above.

Apologies for so many questions again. This bug really has been bothering me a lot in last one year. Your expert advice is very much appreciated! Thanks!

Helico_expert
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Joined: Tue Mar 01, 2011 11:20 pm

Re: Question re: how to to take Quadruple therapy

Post by Helico_expert » Tue Dec 13, 2016 3:03 am

1. Antibiotics wipe out most of your guts bacteria. Some weird ones will survive and can create all sort of digestive problems. So I am not surprise with the gas and bloating.

2. It is normal to stop all medication and wait 4 weeks for the follow up breath test. Only patients with ulcers need to continue PPI for another 4 weeks, then stop for another 2 weeks for follow up breath test.

3. Antibiotics may give you side effects, but not towards the inflammation of the stomach.

4. Some studies suggest that antibiotic resistant strains do go away after some time. However, it is not something that we have monitored. So I am not sure. Since you have done so many trials of antibiotics, I think you should find a specialist who has access to H. pylori culture. If they can grow H. pylori, then they can test out exactly what antibiotics it is sensitive to and prescribe you the best combination. This is what we do here and we have a success rate of over 90% among the multi drug resistant H. pylori.

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