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Gastric cancer and Hp genomics internal project

One of the first bugs to be sequenced, H.pylori has a small genome (1.6 MD) befitting its lifestyle in a hostile acidic mucosal niche. Of the 1500 genes, 750-1000 are essential, the others are different in each strain. Hp has an "open pan-Genome" which means the more strains you look at the more genes you will find - i.e. you will never have a complete set of all its possible genes!

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stomach

Gastric cancer and Hp genomics internal project

Post by stomach » Fri May 28, 2010 1:59 am

The International Cancer Genome Consortium (ICGC) was launched to coordinate large-scale cancer genome studies in tumours from 50 different cancer types and/or subtypes that are of clinical and societal importance across the globe. Systematic studies of more than 25,000 cancer genomes at the genomic, epigenomic and transcriptomic levels will reveal the repertoire of oncogenic mutations, uncover traces of the mutagenic influences, define clinically relevant subtypes for prognosis and therapeutic management, and enable the development of new cancer therapies.

Hopefully, this new tech can help us to understand how much Hp has involved in gastric cancer!

rocky123
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Re: Gastric cancer and Hp genomics internal project

Post by rocky123 » Wed Aug 01, 2012 11:37 am

The focus of the laboratory will be on the bacterial pathogen Helicobacter pylori and its role in the induction of gastric malignancies. H. pylori is a highly successful bacterial pathogen that infects and is perfectly adapted to the human stomach. Despite a dramatic decline of infection rates in the developed world in the past 3-4 decades, it still colonizes roughly half of the world’s population.
rocky

indancesky
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Re: Gastric cancer and Hp genomics internal project

Post by indancesky » Thu Aug 02, 2012 3:40 am

Despite a dramatic decline of infection rates in the developed world in the past 3-4 decades, it still colonizes roughly half of the world’s population.

Helico_expert
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Re: Gastric cancer and Hp genomics internal project

Post by Helico_expert » Thu Aug 02, 2012 2:07 pm

Despite a dramatic decline of infection rates in the developed world in the past 3-4 decades, it still colonizes roughly half of the world’s population.
this statement is half true. infection rate in developed world is less than 20%.

stomach

Re: Gastric cancer and Hp genomics internal project

Post by stomach » Thu Aug 02, 2012 2:50 pm

Helico_expert wrote:
Despite a dramatic decline of infection rates in the developed world in the past 3-4 decades, it still colonizes roughly half of the world’s population.
this statement is half true. infection rate in developed world is less than 20%.

So let's have a look at the genomic data that ICGC has sequenced (http://www.icgc.org/icgc/cgp/69/509/70268). I guess it will tell us more exciting stories of gastric cancer....

fruitlover
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Re: Gastric cancer and Hp genomics internal project

Post by fruitlover » Fri Aug 10, 2012 7:59 am

Wow, great info! Yes hopefully, this new tech can help us to understand more about Hp genomics and gastric cancer. Thanks for sharing!

broken850
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Re: Gastric cancer and Hp genomics internal project

Post by broken850 » Mon Oct 01, 2012 6:29 am

I want to get my parents well water tested as soon as possible. I'm not really sure where to start or who to contact. Would someone from Penn State be interested or be able to test our well?
angel

Helico_expert
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Re: Gastric cancer and Hp genomics internal project

Post by Helico_expert » Tue Oct 02, 2012 5:09 am

where is your parents' well? In United State? I think it's very difficult for the well water to be contaminated with H. pylori. Other organism maybe. But not H. pylori.

Helico_expert
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Re: Gastric cancer and Hp genomics internal project

Post by Helico_expert » Tue Dec 18, 2012 7:46 am

you can take the lansoprazole to control your gastric. then take the other two antibiotics plus lansoprazole when you come back after 3 weeks.

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