Announcement:

A new anti-spam extension has been installed in this forum. If you have problem registering or login the forum, please do not hesitate to email the admin.

Contact Admin Click Here

Question about Bismuth based treatment is this dosage right?

Whereas amoxicillin, clarithromycin and an acid pump blocker make up the most widely used treatment, people who are allergic to penicillin, or who have failed treatment, require other antibiotics. Bismuth compounds (Pepto-Bismol or De-Nol) with can be used in various combinations with other antibiotics such as tetracycline, metronidazole, furazolidone, ciprofloxacin etc., especially when other therapy fails.

Moderators: Toni, barjammar, luci2010

James88
Genuine user
Posts: 21
Joined: Tue Oct 11, 2016 4:11 am

Question about Bismuth based treatment is this dosage right?

Post by James88 » Sat Nov 19, 2016 8:16 am

Hi All,

I have been suffering from resistant hpylori for two years have tried numerous treatments, this is the fourth one.

My GI Specialist has recommended a new treatment involving Bismuth.

I would like to check if the dosage is correct as a pharmacist said it was high and thinks the dosage is not right in days in their opinion.

The current medication I have, I have not started taking this treatment until I am 110% sure the dosage is correct.

- 7 x days of Bismuth Capsules 525mg (4 times a day on an empty stomach 1 hour before food, also noted do not take with dairy products)
The pharmacist said they think the correct dosage is 14 days bismuth 4 times a day, I feel their may be an issue with the script.

- 14 x days of Amoxycillin 500mg (two capsules twice a with food)

- 14 x days of Doxycycline 50mg (one tablet twice a day with food)

- 14 x days of Nexium 20mg (one tablet twice a day with food)

Thanks

Jamies

James88
Genuine user
Posts: 21
Joined: Tue Oct 11, 2016 4:11 am

Re: Question about Bismuth based treatment is this dosage right?

Post by James88 » Sun Nov 20, 2016 12:46 pm

Also I noticed many of the cases online are using Metronidazole instead of Amoxycillin in this treatment????

What is the key difference.

Helico_expert
Genuine user
Posts: 2461
Joined: Tue Mar 01, 2011 11:20 pm

Re: Question about Bismuth based treatment is this dosage right?

Post by Helico_expert » Mon Nov 21, 2016 5:47 am

Hi, your bismuth dose is a bit high. I think you need to clarify with your doctor. you sure it's not 525mg/20 or 30 ml?

otherwise, you have a good antibiotic combination.

The reason your doctor prescribe you amoxicillin instead of metronidazole is because he believes your strain is already resistant to metronidazole. Amoxicillin on the other hand, is too hard for H. pylori to overcome. We have not seen a real amoxicillin resistant strain to date. all the reports out there with amoxicillin resistance, they have a very low cut off value which we think it's not appropriate because we can take very high dose of amoxicillin. Hence, there is no need for a low cut off value to determine if it is resistant.

James88
Genuine user
Posts: 21
Joined: Tue Oct 11, 2016 4:11 am

Re: Question about Bismuth based treatment is this dosage right?

Post by James88 » Wed Nov 23, 2016 5:48 am

DR Said the following "The dosage is 525mg four times daily and should be taken for 14 days. I will post a script for the second 7 days for the Bismuth today."

I found a few sources online which note 525mg dose is fine -
http://www.mayoclinic.org/drugs-supplem ... g-20061526
http://emedicine.medscape.com/article/2172395-overview

James

Helico_expert
Genuine user
Posts: 2461
Joined: Tue Mar 01, 2011 11:20 pm

Re: Question about Bismuth based treatment is this dosage right?

Post by Helico_expert » Thu Nov 24, 2016 4:58 am

thanks for sharing the information. do keep us posted how you feel during the treatment.
:)

James88
Genuine user
Posts: 21
Joined: Tue Oct 11, 2016 4:11 am

Re: Question about Bismuth based treatment is this dosage right?

Post by James88 » Thu Feb 23, 2017 7:37 am

Good news after taking this Bismuth treatment late last year it seems to have worked as I had a follow up breath test after 2 weeks with no Nexium

Received these test results -

"Your recent breath test showed that the bacterial Helicobacter Pylori has been eradicated. "

My advice to anyone who has not tried the Bismuth treatment is to give it a shot!

Helico_expert
Genuine user
Posts: 2461
Joined: Tue Mar 01, 2011 11:20 pm

Re: Question about Bismuth based treatment is this dosage right?

Post by Helico_expert » Tue Apr 18, 2017 2:04 pm

Congratulation! thank you for sharing the good news.

LeandroSalvatore
Genuine user
Posts: 5
Joined: Sat Oct 07, 2017 3:51 pm

Re: Question about Bismuth based treatment is this dosage right?

Post by LeandroSalvatore » Sat Oct 07, 2017 4:12 pm

Hi James!

I'm happy that you got rid of h pylori :))
You say that you had been suffering from resistant hpylori for two years and tried numerous treatments prior to this therapy.
I'm in a similar situation.

Can you please write which particular 3 regiments you tried BEFORE the successful fourth attempt with Quadruple therapy??

In particular, did any of those 3 prior treatments involve Amoxycillin?

LeandroSalvatore
Genuine user
Posts: 5
Joined: Sat Oct 07, 2017 3:51 pm

Re: Question about Bismuth based treatment is this dosage right?

Post by LeandroSalvatore » Sat Oct 07, 2017 4:13 pm

About my situation:

I was first treated with tripple therapy of Amoxicilline, Clarithromycin and Omeprazole. It was successful, h pylori was eradicated, which was confirmed by a biopsy.
Then, some time later, I got reinfected and tried exactly the same tripple therapy that worked the first time round. But this time it failed.
Third time round I tried Quadruple therapy consisting of Bismuth, Metronidazole Tetracycline and Omeprazole. But I did something stupid - I took all the meds together with food. I only realised that I was doing it wrong on day 10. So, the treatment failed.

The doctors where I live are horrible, so I'm having to rely on my own research in terms of treatment.

Helico_expert
Genuine user
Posts: 2461
Joined: Tue Mar 01, 2011 11:20 pm

Re: Question about Bismuth based treatment is this dosage right?

Post by Helico_expert » Sun Oct 08, 2017 12:28 pm

For your information,

1. Amoxycillin and Bismuth can be taken over and over again. H. pylori cannot become resistant to Amoxycillin and Bismuth.
2. It's ok to take antibiotics with food. In fact, we always ask our patients to take the treatment with food.

So your next treatment, can be PPI + Bismuth + Amox + something that you had not tried before.

Post Reply

Return to “Bismuth and Other Less Common Antibiotics”